Table 1 Experimental protocols
From: Platelet rich clots are resistant to lysis by thrombolytic therapy in a rat model of embolic stroke
| Study 1 | Study 2 | |
|---|---|---|
| Location | Newcastle, Australia | Bad Nauheim, Germany |
| Aim | Develop model, Determine spontaneous recanalization rate | Determine recanalization rates with microbubble + sonothrombolysis enhancement of tPA |
| Primary Outcome [method] | Recanalization [Laser Doppler] | Recanalization [Laser Doppler] |
| Secondary Outcome(s) [method] | Infarct Volumes [TTC], Mortality, Neurological Deficit scores | Clot lysis [Inspection of the major branches of the cerebral arterial circulation] |
| Survival post-embolism | 24 h | 2 h |
| Treatment groups (n) | No treatment (n = 7) | Saline (n = 10), tPA (n = 10), tPA + Ultrasound + BR38 microbubbles (n = 10) |
| Laser Doppler Monitoring | Continuous | Discontinuous |
| To 4 h post-embolism | Pre-embolism, Post-embolism, Pre-treatment, Post-treatment |